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Prediction of vitamin D defficiency by simple patient characteristics.
- Source :
- American Journal of Clinical Nutrition; May2014, Vol. 99 Issue 5, p1089-1095, 7p, 5 Charts
- Publication Year :
- 2014
-
Abstract
- Background: Vitamin D Status is currently diagnosed by measuring serum 25-hydroxyvitamin D [25(OH)D]. Objective: This study aimed to develop a risk profile that can be used to easily identify older individuals at high risk of vitamin D deficiency. Design: This study was performed within the Longitudinal Aging Study Amsterdam, an ongoing cohort study in a representative sample of the Dutch older population (n = 1509 for the development sample and n = 1100 for the Validation sample). Prediction models for serum 25(OH)D concentrations <50 and <30 nmol/L were developed by using backward logistic regression. Risk scores were calculated by dividing the individual regression coefficients by the regression coefficient with the lowest β to create simple scores. Results: Serum 25(OH)D concentrations <50 and <30 nmol/L were present in 46.2% and 17.5% of participants, respectively. The model for the prediction of concentrations <50 nmol/L consisted of 13 easily assessable predictors, whereas the model for concentrations <30 nmol/L contained 10 predictors. The resulting areas under the curve (AUCs) were 0.78 and 0.80, respectively. The AUC in the ex-ternal Validation data set was 0.71 for the <50-nmol/L model. At a cutoff of 58 in total risk score (range: 8-97), the model predicted concentrations <50 nmol/L with a sensitivity of 61% and a specificity of 82%, whereas these values were 61% and 84%, respectively, at a cutoff of 110 in the total risk score (range: 6-204) in the model for concentrations <30 nmol/L. Conclusions: Two total risk scores, including 13 or 10 predictors that can easily be assessed, were developed and are able to predict serum 25(OH)D concentrations <50 and <30 nmol/L accurately. These risk scores may be useful in clinical practice to identify persons at risk of vitamin D deficiency. [ABSTRACT FROM AUTHOR]
- Subjects :
- DIETARY supplements
VITAMIN D deficiency
SMOKING
EDUCATIONAL attainment
AGE distribution
GERIATRIC nutrition
ANXIETY
DRUG therapy
COGNITION
CONFIDENCE intervals
MENTAL depression
ALCOHOL drinking
EPIDEMIOLOGY
HEALTH status indicators
INTERVIEWING
LIFE skills
LONGITUDINAL method
MARITAL status
MATHEMATICS
NEUROPSYCHOLOGICAL tests
MEMORY disorders
PAIN
PSYCHOLOGICAL tests
QUESTIONNAIRES
REGRESSION analysis
RESEARCH evaluation
RESEARCH funding
SEASONS
SEX distribution
VITAMIN D
WALKING
LOGISTIC regression analysis
DATA analysis
BODY mass index
PHYSICAL activity
DATA analysis software
DESCRIPTIVE statistics
OLD age
DIAGNOSIS
VITAMIN deficiency
Subjects
Details
- Language :
- English
- ISSN :
- 00029165
- Volume :
- 99
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 95669739
- Full Text :
- https://doi.org/10.3945/ajcn.113.076430