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Sugars and risk of mortality in the NIH-AARP Diet and Health Study.
- Source :
- American Journal of Clinical Nutrition; May2014, Vol. 99 Issue 5, p1077-1088, 12p, 1 Black and White Photograph, 5 Charts
- Publication Year :
- 2014
-
Abstract
- Background: Although previous studies have linked intake of sugars with incidence of cancer and other chronic diseases, its association with mortality remains unknown. Objective: We investigated the association of total sugars, added sugars, total fructose, added fructose, sucrose, and added sucrose with the risk of all-cause, cardiovascular disease, cancer, and other-cause mortality in the NIH-AARP Diet and Health Study. Design: The participants (n = 353,751), aged 50-71 y, were followed for up to 13 y. Intake of individual sugars over the previous 12 mo was assessed at baseline by using a 124-item NIH Diet History Questionnaire. Results: In fully adjusted models (fifth quartile compared with first quartile), all-cause mortality was positively associated with the intake of total sugars [HR (95% CI): 1.13 (1.06, 1.20); P-trend, 0.0001], total fructose [1.10 (1.04, 1.17); P-trend, 0.0001], and added fructose [1.07 (1.01, 1.13); P-trend = 0.005) in women and total fructose [1.06 (1.01, 1.10); P-trend = 0.002] in men. In men, a weak inverse association was found between other-cause mortality and dietary added sugars (P-trend = 0.04), sucrose (P-trend = 0.03), and added sucrose (P-trend = 0.006). Investigation of consumption of sugars by source showed that the positive association with mortality risk was confined only to sugars from beverages, whereas the inverse association was confined to sugars from solid foods. Conclusions: In this large prospective study, total fructose intake was weakly positively associated with all-cause mortality in both women and men, whereas added sugar, sucrose, and added sucrose intakes were inversely associated with other-cause mortality in men. In our analyses, intake of added sugars was not associated with an increased risk of mortality. The NIH-AARP Diet and Health Study was registered at clinicaltrials.gov as NCT00340015. [ABSTRACT FROM AUTHOR]
- Subjects :
- BEVERAGES
CARDIOVASCULAR diseases
CONFIDENCE intervals
EPIDEMIOLOGY
EPIDEMIOLOGICAL research
SUGAR content of food
FRUCTOSE
LONGITUDINAL method
MORTALITY
NUTRITIONAL assessment
QUESTIONNAIRES
RESEARCH funding
STATISTICAL hypothesis testing
SUCROSE
TUMORS
DATA analysis
PROPORTIONAL hazards models
DATA analysis software
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 00029165
- Volume :
- 99
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 95669738
- Full Text :
- https://doi.org/10.3945/ajcn.113.069369