Back to Search Start Over

Deciphering Proneurotrophin Actions.

Authors :
Hempstead, B. L.
Source :
Neurotrophic Factors (9783642451058); 2014, p17-32, 16p
Publication Year :
2014

Abstract

Like most growth factors, neurotrophins are initially synthesized as precursors that are cleaved to release C-terminal mature forms. The well-characterized mature neurotrophins bind to Trk receptors to initiate survival and differentiative responses. More recently, the precursor forms or proneurotrophins have been found to act as distinct ligands by binding to an unrelated receptor complex consisting of the p75 neurotrophin receptor (p75) and sortilin to initiate cell death. Induction of proNGF and p75 has been observed in preclinical injury models and in pathological states in the central nervous system, and strategies that block the proNGF/p75 interaction are effective in limiting neuronal apoptosis. In contrast, the mechanisms that regulate expression of other proneurotrophins, including proBDNF and proNT-3, are less well understood. Here, recent findings on the biological actions, regulation of expression, and pathophysiological effects of proneurotrophins will be reviewed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISBNs :
9783642451058
Database :
Complementary Index
Journal :
Neurotrophic Factors (9783642451058)
Publication Type :
Book
Accession number :
95565725
Full Text :
https://doi.org/10.1007/978-3-642-45106-5_2