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Electroacupuncture Ameliorates Learning and Memory via Activation of the CREB Signaling Pathway in the Hippocampus to Attenuate Apoptosis after Cerebral Hypoperfusion.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 2013, Vol. 2013, p1-8, 8p, 1 Diagram, 4 Graphs
- Publication Year :
- 2013
-
Abstract
- Studies have shown that electroacupuncture (EA) ameliorates learning and memory after ischemic injury. However, there have been few studies elucidating the mechanisms of EA on learning and memory in cerebral hypoperfusion. In this study, we explored the cAMP response element-binding protein (CREB) signaling pathway-mediated antiapoptotic action involved in EA-induced improvement of learning and memory. EA at GV20 and GV14 acupoints was applied in cerebral hypoperfusion rats. A Morris water maze task was performed, and the immunoreactivities of pCREB, Bcl-2, and Bax in the hippocampal CA1 area were evaluated by the Western blotting technique. Our findings indicated that (1) EA ameliorated spatial learning and memory impairment in cerebral hypoperfusion rats; (2) EA increased the immunoreactivities of pCREB and Bcl-2 and decreased the immunoreactivity of Bax; (3) intracerebroventricular administration of H89 (the inhibitor of protein kinase A) blocked EA-induced, pCREB-mediated antiapoptotic action and improved learning and memory. These results suggest that EA can ameliorate learning and memory via activation of the CREB signaling pathway in the hippocampus to attenuate apoptosis after cerebral hypoperfusion. [ABSTRACT FROM AUTHOR]
- Subjects :
- BRAIN physiology
COGNITION disorders diagnosis
HIPPOCAMPUS (Brain)
ELECTROACUPUNCTURE methodology
ACADEMIC medical centers
ALTERNATIVE medicine
ANALYSIS of variance
ANIMAL experimentation
APOPTOSIS
GROWTH factors
LEARNING
MEDICAL care
MEMORY
PATIENTS
RATS
STROKE
T-test (Statistics)
DATA analysis
DESCRIPTIVE statistics
DISEASE complications
ANATOMY
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2013
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 95496198
- Full Text :
- https://doi.org/10.1155/2013/156489