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Swimming Training Prevents Alterations in Acetylcholinesterase and Butyrylcholinesterase Activities in Hypertensive Rats.
- Source :
- American Journal of Hypertension; Apr2014, Vol. 27 Issue 4, p522-529, 8p
- Publication Year :
- 2014
-
Abstract
- BACKGROUND Cholinergic enzyme activities are altered in hypertension, reflecting a low-grade inflammation. Regular physical exercise exerts anti-inflammatory effects and has been described as a coadjutant in the treatment of hypertension. In this study, we investigated the effect of 6 weeks of swimming training on cholinergic enzyme activities (acetylcholinesterase and butyrylcholinesterase) in Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME)–induced hypertensive rats. METHODS The rats were divided into 4 groups: control (n = 10), exercise (n = 10), L-NAME (n = 10), and exercise L-NAME (n = 10). The animals were trained 5 times per week in an adapted swimming system for 60 minutes with a gradual increase of the workload up to 5% of animal’s body weight. Enzyme activities were measured spectrophotometrically in lymphocytes, whole blood, and serum. RESULTS A significant rise in acetylcholinesterase activity was observed in lymphocytes and whole blood as well as in serum butyrylcholinesterase activity in the L-NAME group when compared with the other groups (P < 0.05), and the increase in cholinesterase activities was positively correlated with the rise in blood pressure (r = 0.5721, r = 0.6121, and r = 0.5811, respectively). Swimming training was efficient in preventing these alterations in the exercise L-NAME group, which displayed values similar to those of the control group. Exercise training demonstrated a significant hypotensive effect in hypertensive rats. CONCLUSIONS Exercise training was shown to prevent increased cholinesterase related to inflammatory processes in hypertensive rats, providing a new insight about protective exercise mechanisms to avoid hypertension-related inflammation. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 08957061
- Volume :
- 27
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- American Journal of Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 95094555
- Full Text :
- https://doi.org/10.1093/ajh/hpt030