Synthesis and biological evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents.

A series of novel N-arylpyrazole derivatives, 5a- 5i, were achieved from substituted phenylacetic acid via Vilsmeier-Haack reaction, hydrolysis, condensation, and aromatic substitution reaction. Their chemical structures were confirmed by H NMR, C NMR, FTIR, HRMS, and elemental analysis. The newly synthesized compounds were tested for their in vitro cytotoxic activity against Bel-7402, KB, HL-60, and BGC-823 cell lines and found to possess moderate activity. [ABSTRACT FROM AUTHOR]