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Antiepileptic Medications in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
- Source :
- Journal of Autism & Developmental Disorders; Apr2014, Vol. 44 Issue 4, p948-957, 10p, 2 Diagrams, 2 Graphs
- Publication Year :
- 2014
-
Abstract
- Electroencephalogram-recorded epileptiform activity is common in children with autism spectrum disorder (ASD), even without clinical seizures. A systematic literature search identified 7 randomized, placebo-controlled trials of antiepileptic drugs (AEDs) in ASD (total n = 171), including three of valproate, and one each of lamotrigine, levetiracetam, and topiramate. Meta-analysis revealed no significant difference between medication and placebo in four studies targeting irritability/agitation and three studies investigating global improvement, although limitations include lack of power and different medications with diverse actions. Across all seven studies, there was no significant difference in discontinuation rate between two groups. AEDs do not appear to have a large effect size to treat behavioral symptoms in ASD, but further research is needed, particularly in the subgroup of patients with epileptiform abnormalities. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTICONVULSANTS
AUTISM
CINAHL database
CONFIDENCE intervals
ELECTROENCEPHALOGRAPHY
EPIDEMIOLOGY
INFORMATION storage & retrieval systems
MEDICAL databases
MEDICAL information storage & retrieval systems
PSYCHOLOGY information storage & retrieval systems
MEDLINE
META-analysis
ONLINE information services
SYSTEMATIC reviews
DATA analysis
RANDOMIZED controlled trials
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 01623257
- Volume :
- 44
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Autism & Developmental Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 94772581
- Full Text :
- https://doi.org/10.1007/s10803-013-1952-2