Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegeneration.

The article presents a study which investigates the synaptic mechanism of inflammatory neurodegeneration in progressive multiple sclerosis (MS). Details about the methods of the study are provided. An observation of an increased spontaneous excitatory postsynaptic currents, along with the pathogenic role of B cells in tumor necrosis factor (TNF) cerebrospinal fluid increase, is discussed. The study suggests TNF as a major neurotoxic molecule in progressive MS.