One-pot three-component synthesis of substituted 2-(1,2,3-triazol-1-yl)pyrimidines from pyrimidin-2-yl sulfonates, sodium azide and active methylene ketones.

New 2-(1,2,3-triazol-1-yl)pyrimidines were synthesized in good yields by the three-component reaction of pyrimidin-2-yl sulfonates, sodium azide and active methylene ketones in the presence of K₂CO₃ at room temperature. This procedure eliminates the need to handle organic azides in the synthesis of analogous compounds. [ABSTRACT FROM AUTHOR]