What are the abnormal thrombotic responses in the clotting system of individuals with atherosclerosis? Are these responses genetically determined or adaptations to the disease state?

The article focuses on abnormal thrombotic responses in the clotting system of people with atherosclerosis and discusses whether the responses have a genetic basis or are simply adaptations to the disease state. Topics discussed include blood-coagulation mechanism as a collection of zymogen-to-enzyme transformations, cellular adhesive reactions and association of thrombosis with occlusion of a blood vessels, and antithrombin Ill-heparin anticoagulant and the activated protein C pathway.