Synthesis, Characterization and Biological Evaluation of Two Silver(I) trans-Cinnamate Complexes as Urease Inhibitors.

Two new silver(I) trans-cinnamates, namely [Ag(2-cca)(H₂O)]₂ ( 1) and [Ag(4-cca)] _n ( 2) (2-ccaH = 2-chlorocinnamic acid and 4-ccaH = 4-chlorocinnamic acid), were synthesized and structurally characterized. Single crystal X-ray studies reveal that each silver(I) atom in 1 is two-coordinate by a 2-chlorocinnamate ligand and one water molecule to afford a discrete centrosymmetric dimer with the ligand-unsupported Ag···Ag interactions (3.218(4) Å), while a pair of symmetry-related silver(I) atoms in 2 are clamped by two μ₂-η¹:η¹ 4-chlorocinnamate ligands to yield a binuclear silver(I) moiety incorporating a ligand-supported Ag···Ag interaction (2.819(5) Å). Both complexes 1 and 2 show potent urease inhibitory activities with the respective IC₅₀ values of 0.66 and 1.10 μM. [ABSTRACT FROM AUTHOR]