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Effects of an epidermal growth factor receptor-based cancer vaccine on wound healing and inflammation processes in murine experimental models.
- Source :
- International Wound Journal; Feb2014, Vol. 11 Issue 1, p98-103, 6p, 4 Charts
- Publication Year :
- 2014
-
Abstract
- Anti-epidermal growth factor receptor (EGFR) therapies have been proven clinically effective for a variety of epithelial tumours. Vaccination of mice with the extracellular domain (ECD) of autologous EGFR overcomes the tolerance to self-EGFR and has antimetastatic effect on EGFR+ tumour. Because EGF/EGFR-signalling plays an important role in the inflammation stage of wound healing, the main objective of this study was to explore the possible role of murine (m) EGFR-ECD vaccine in the croton-oil-induced ear oedema and wound healing process in mice as autologous experimental models, mimicking the possible post-surgical wound complication in patients treated with human EGFR-ECD/VSSP vaccine. Mice were intramuscularly immunised four times; biweekly with the mEGFR-ECD/VSSP/Mont. Seven days later, an 8 mm diameter, full-thickness skin wound was created on the back of each animal. Immunisation induced a strong specific humoral response against the mEGFR-ECD protein and a DTH dose-response curve but interestingly, animals treated with mEGFR-ECD/VSSP/Mont had similar inflammatory and healing speed responses compared to control ones. These data suggest that application of mEGFR-ECD/VSSP vaccine as a therapeutic approach in cancer patients could not elicit a poor healing process after surgery. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANALYSIS of variance
ANIMAL experimentation
BIOLOGICAL models
CHI-squared test
DOSE-response relationship in biochemistry
EPIDERMAL growth factor
EPITHELIAL cell tumors
IMMUNOTHERAPY
INFLAMMATION
MEDICAL protocols
MICE
STATISTICAL hypothesis testing
STATISTICS
T-test (Statistics)
U-statistics
WOUND healing
DATA analysis
CANCER vaccines
Subjects
Details
- Language :
- English
- ISSN :
- 17424801
- Volume :
- 11
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- International Wound Journal
- Publication Type :
- Academic Journal
- Accession number :
- 93876980
- Full Text :
- https://doi.org/10.1111/j.1742-481X.2012.01074.x