Two new 20α(H)-ursane-type triterpenoids from Ilex cornuta and their cytotoxic activities.

Two new 20α-ursane-type triterpenoids (1–2) were isolated from the roots ofIlex cornuta, along with three known triterpenoids (3–5). The structures of compounds1–2were determined as 3β, 23-dihydroxy-20α(H)-urs-12-en-28-oic acid (1), 3β,19α,23-trihydroxy-20α(H)-urs-12-en-28-oic acid 3β-O-α-l-arabinopyranoside (2), on the basis of hydrolysis and spectral evidence, including 1D- and 2D-NMR and high-resolution electrospray ionization mass spectrometry analyses. These pure isolates (1–5) were tested for their cytotoxic activities by MTT assay. [ABSTRACT FROM PUBLISHER]