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Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort.
- Source :
- British Journal of Psychiatry; Jan2014, Vol. 204 Issue 1, p40-45, 6p
- Publication Year :
- 2014
-
Abstract
- Background Tourette syndrome and chronic tic disorder are heritable but aetiologically complex. Although environment plays a role in their development, existing studies of non-genetic risk factors are inconsistent. Aims TO examine the association between pre- and perinatal exposures and Tourette syndrome/chronic tic disorder in the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective longitudinal pre-birth cohort. Method Relationships between exposures and Tourette syndrome/ chronic tic disorder were examined in 6090 children using logistic regression. Results Maternal alcohol and cannabis use, inadequate maternal weight gain and parity were associated with Tourette syndrome or Tourette syndrome/chronic tic disorder. Other previously reported exposures, including birth weight and prenatal maternal smoking, were not associated with Tourette syndrome/chronic tic disorder. Conclusions This study supports previously reported relationships between Tourette syndrome/chronic tic disorder and prenatal alcohol exposure, and identifies additional previously unexplored potential prenatal risk factors. [ABSTRACT FROM AUTHOR]
- Subjects :
- TOURETTE syndrome
TIC disorders
PERINATOLOGY
PARENT-child relationships
PSYCHIATRIC research
COMPLICATIONS of alcoholism
APGAR score
CONFIDENCE intervals
EPIDEMIOLOGY
LONGITUDINAL method
PROBABILITY theory
QUESTIONNAIRES
RESEARCH funding
LOGISTIC regression analysis
DATA analysis
PRENATAL exposure delayed effects
PREGNANCY
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 00071250
- Volume :
- 204
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- British Journal of Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 93726674
- Full Text :
- https://doi.org/10.1192/bjp.bp.112.125468