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Schwann cells seeded in acellular nerve grafts improve functional recovery.
- Source :
- Muscle & Nerve; Feb2014, Vol. 49 Issue 2, p267-276, 10p
- Publication Year :
- 2014
-
Abstract
- ABSTRACT Introduction: This study evaluated whether Schwann cells (SCs) from different nerve sources transplanted into cold-preserved acellular nerve grafts (CP-ANGs) would improve functional regeneration compared with nerve isografts. Methods: SCs isolated and expanded from motor and sensory branches of rat femoral and sciatic nerves were seeded into 14mm CP-ANGs. Growth factor expression, axonal regeneration, and functional recovery were evaluated in a 14-mm rat sciatic injury model and compared with isografts. Results: At 14 days, motor or sensory-derived SCs increased expression of growth factors in CP-ANGs versus isografts. After 42 days, histomorphometric analysis found CP-ANGs with SCs and isografts had similar numbers of regenerating nerve fibers. At 84 days, muscle force generation was similar for CP-ANGs with SCs and isografts. SC source did not affect nerve fiber counts or muscle force generation. Conclusions: SCs transplanted into CP-ANGs increase functional regeneration to isograft levels; however SC nerve source did not have an effect. Muscle Nerve 49: 267-276, 2014 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0148639X
- Volume :
- 49
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Muscle & Nerve
- Publication Type :
- Academic Journal
- Accession number :
- 93678131
- Full Text :
- https://doi.org/10.1002/mus.23885