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Immunogenicity and efficacy of a chimpanzee adenovirus-vectored Rift Valley Fever vaccine in mice.
- Source :
- Virology Journal; 2013, Vol. 10 Issue 1, p1-21, 20p, 1 Chart, 3 Graphs
- Publication Year :
- 2013
-
Abstract
- Background Rift Valley Fever (RVF) is a viral zoonosis that historically affects livestock production and human health in sub-Saharan Africa, though epizootics have also occurred in the Arabian Peninsula. Whilst an effective live-attenuated vaccine is available for livestock, there is currently no licensed human RVF vaccine. Replication-deficient chimpanzee adenovirus (ChAd) vectors are an ideal platform for development of a human RVF vaccine, given the low prevalence of neutralizing antibodies against them in the human population, and their excellent safety and immunogenicity profile in human clinical trials of vaccines against a wide range of pathogens. Methods Here, in BALB/c mice, we evaluated the immunogenicity and efficacy of a replicationdeficient chimpanzee adenovirus vector, ChAdOx1, encoding the RVF virus envelope glycoproteins, Gn and Gc, which are targets of virus neutralizing antibodies. The ChAdOx1- GnGc vaccine was assessed in comparison to a replication-deficient human adenovirus type 5 vector encoding Gn and Gc (HAdV5-GnGc), a strategy previously shown to confer protective immunity against RVF in mice. Results A single immunization with either of the vaccines conferred protection against RVF virus challenge eight weeks post-immunization. Both vaccines elicited RVF virus neutralizing antibody and a robust CD8+ T cell response. Conclusions Together the results support further development of RVF vaccines based on replicationdeficient adenovirus vectors, with ChAdOx1-GnGc being a potential candidate for use in future human clinical trials. [ABSTRACT FROM AUTHOR]
- Subjects :
- RIFT Valley fever
ARBOVIRUS diseases
VACCINATION
VIRAL hepatitis
Subjects
Details
- Language :
- English
- ISSN :
- 1743422X
- Volume :
- 10
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Virology Journal
- Publication Type :
- Academic Journal
- Accession number :
- 93597575
- Full Text :
- https://doi.org/10.1186/1743-422X-10-349