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Evaluation of the Antipruritic Effects of Topical Pimecrolimus in Non-Atopic Prurigo Nodularis: Results of a Randomized, Hydrocortisone-Controlled, Double-Blind Phase II Trial.
- Source :
- Dermatology (10188665); Jan2014, Vol. 227 Issue 4, p353-360, 8p, 1 Diagram, 1 Chart, 2 Graphs
- Publication Year :
- 2014
-
Abstract
- Background: In the treatment of atopic dermatitis, pimecrolimus has high antipruritic effects. Objective: To investigate the efficacy of 1% pimecrolimus cream in comparison to 1% hydrocortisone cream in non-atopic prurigo nodularis (PN). Methods: A randomized, controlled, double-blind study with intraindividual randomization was done in 30 patients (17 females, 13 males; mean age 58.5 years) with PN. Results: Pruritus intensity decreased significantly (p < 0.001) on both treated sides as early as after 10 days of treatment; scratch lesions improved (p < 0.001). Quality of life as assessed by the Dermatology Life Quality Index improved significantly. However, a significant advantage of pimecrolimus over hydrocortisone was not found. Conclusion: The results suggest that the non-steroid pimecrolimus is an effective alternative for PN treatment. © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10188665
- Volume :
- 227
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Dermatology (10188665)
- Publication Type :
- Academic Journal
- Accession number :
- 93547955
- Full Text :
- https://doi.org/10.1159/000355671