Distribution of Alpha-Tubulin in Rat Forebrain Structures.

Immunohistochemical studies addressed the distribution of α-tubulin microtubules in rat forebrain structures. Non-uniform staining was seen with the reaction for α-tubulin. High immunoreactivity was detected in the cingulate and piriform cortex, olfactory bulbs, and the optic chiasma. The weakest immunohistochemical reactions were seen in the corpus striatum, the superficial layers of the septum, the cingulum, and structures around the third ventricle. Immunoreactivity in neurons was clearly apparent at the periphery of the perikaryon and in the apical dendrite. It is suggested that the intensity of the immunohistochemical reaction for α-tubulin may reflect the functional state of neurons. [ABSTRACT FROM AUTHOR]