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Linear growth increased in young children in an urban slum of Haiti: a randomized controlled trial of a lipid-based nutrient supplement.
- Source :
- American Journal of Clinical Nutrition; Jan2014, Vol. 99 Issue 1, p198-208, 11p, 1 Diagram, 4 Charts, 3 Graphs
- Publication Year :
- 2014
-
Abstract
- Background: Haiti has experienced rapid urbanization that has exacerbated poverty and undernutrition in large slum areas. Stunting affects 1 in 5 young children. Objective: We aimed to test the efficacy of a daily lipid-based nutrient supplement (LNS) for increased linear growth in young children. Design: Healthy, singleton infants aged 6-11 mo (n = 589) were recruited from an urban slum of Cap Haitien and randomly assigned to receive: 1) a control; 2) a 3-mo LNS; or 3) a 6-mo LNS. The LNS provided 108 kcal and other nutrients including vitamin A, vitamin B-12, iron, and zinc at ⩾80% of the recommended amounts. Infants were followed monthly on growth, morbidity, and developmental outcomes over a 6-mo intervention period and at one additional time point 6 mo postintervention to assess sustained effects. The Bonferroni multiple comparisons test was applied, and generalized least-squares (GLS) regressions with mixed effects was used to examine impacts longitudinally. Results: Baseline characteristics did not differ by trial arm except for a higher mean age in the 6-mo LNS group. GLS modeling showed LNS supplementation for 6 mo significantly increased the length-for-age z score (±SE) by 0.13 ± 0.05 and the weight-for-age z score by 0.12 ± 0.02 compared with in the control group after adjustment for child age (P <0.001). The effects were sustained 6 mo postintervention. Morbidity and developmental outcomes did not differ by trial arm. Conclusion: A low-energy, fortified product improved the linear growth of young children in this urban setting. The trial was registered at clinicaltrials.gov as NCT01552512 [ABSTRACT FROM AUTHOR]
- Subjects :
- ENRICHED foods
ANALYSIS of variance
ANTHROPOMETRY
BREASTFEEDING
CHI-squared test
CLINICAL trials
DIETARY supplements
ELEMENTAL diet
HUMAN growth
INFANT development
INFANT nutrition
INGESTION
LIPIDS
LONGITUDINAL method
MOTHERS
HEALTH outcome assessment
POVERTY
QUESTIONNAIRES
REGRESSION analysis
RESEARCH funding
STATISTICAL sampling
STATISTICS
T-test (Statistics)
VITAMINS
STATISTICAL power analysis
DATA analysis
SOCIOECONOMIC factors
STATISTICAL significance
BODY mass index
RANDOMIZED controlled trials
TREATMENT effectiveness
PRE-tests & post-tests
DATA analysis software
DESCRIPTIVE statistics
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 00029165
- Volume :
- 99
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 93417619
- Full Text :
- https://doi.org/10.3945/ajcn.113.063883