Mathematical validation of a biological model for unlinking replication catenanes by recombination.

Authors :: Jayaram, Makkuni
Source :: Proceedings of the National Academy of Sciences of the United States of America; 12/24/2013, Vol. 110 Issue 52, p20854-20855, 2p
Publication Year :: 2013
Abstract: The article focuses on a study regarding a mathematical validation of biologists' intuitive model for unlinking catalyzed by FtsK-XerCD system. It is mentioned that tangle analysis, which has been successfully applied to deduce strand exchange mechanisms catalyzed by site-specific recombinases is used in the study. The general problem of topology simplification in DNA is described.

Language :: English
ISSN :: 00278424
Volume :: 110
Issue :: 52
Database :: Complementary Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 93379689
Full Text :: https://doi.org/10.1073/pnas.1321214111

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