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HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation.
- Source :
- FEBS Letters; Jan2014, Vol. 588 Issue 1, p143-150, 8p
- Publication Year :
- 2014
-
Abstract
- Highlights: [•] HtrA1 is secreted by osteoclasts. [•] HtrA1 inhibits osteoblast differentiation. [•] HtrA1 inhibits osteoblast activities through the inhibition of BMP2-induced signaling. [•] HtrA1 is identified as a new osteoclast-derived factor regulating osteoblasts. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 588
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 93334804
- Full Text :
- https://doi.org/10.1016/j.febslet.2013.11.022