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Anti HSV-1 Flavonoid Derivatives Tethered with Houttuynin from Houttuynia cordata.

Authors :
Shao-Dan Chen
Ting Li
Hao Gao
Qin-Chang Zhu
Chuan-Jian Lu
Hong-Ling Wu
Tao Peng
Xin-Sheng Yao
Source :
Planta Medica; Dec2013, Vol. 79 Issue 18, p1742-1748, 7p
Publication Year :
2013

Abstract

This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of the new compounds was obtained as a pair of inseparable diasteriomeric epimers due to the chiral carbon of hemiketal at C-3". This phenomenon is rooted in the ring-chain tautomerism of the hemiketal functional group in solution, which was proved by dynamic NMR experiments. The new compounds 1-4 displayed inhibitory activities against herpes simplex virus 1, with respective IC50 values of 38.46, 14.10, 62.00 and 70.76 μM, which was associated with the medicinal functions of H. cordata. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00320943
Volume :
79
Issue :
18
Database :
Complementary Index
Journal :
Planta Medica
Publication Type :
Periodical
Accession number :
93312965
Full Text :
https://doi.org/10.1055/s-0033-1351051