1974-2014: Reflections on the evolution of clinical pharmacology in the past 40 years and a message to our readers.

The article presents the author's insights concerning the developments in clinical pharmacology from 1974-2014. It highlights the research articles published in the journal which focused on pharmacodynamics, pharmacokinetics, drug metabolism, therapeutics, and analytical methodology. It cites the changes which include changes in intellectual approach and theory and advances that have occurred in some areas of therapeutics.