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Safety and efficacy of aerobic training in operable breast cancer patients receiving neoadjuvant chemotherapy: A phase II randomized trial.
- Source :
- Acta Oncologica; Jan2014, Vol. 53 Issue 1, p65-74, 10p, 1 Diagram, 3 Charts
- Publication Year :
- 2014
-
Abstract
- Background. To evaluate the safety and efficacy of moderate-to-high intensity aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Methods. Twenty patients with stage IIB-IIIC operable breast cancer were randomly assigned to receive doxorubicin plus cyclophosphamide (AC) or AC in combination with aerobic training (AC + AET) (n = 10/group) for 12 weeks. The AC+ AET group performed three supervised aerobic cycle ergometry sessions per week at 60%-100% of exercise capacity (VO<subscript>2peak</subscript>). Safety outcomes included exercise testing as well as treatment- and exercise training-related adverse events (AEs), whereas efficacy outcomes included cardiopulmonary function and patient-reported outcomes (PROs) as measured by a cardiopulmonary exercise test (CPET) and Functional Assessment of Cancer Therapy-Breast (FACT-B) scale. Results. Twelve non-significant ECG abnormalities and three non-life threatening events occurred during CPET procedures. One AE was reported during aerobic training. There were no significant between group differences for clinician-documented events (e.g. pain, nausea) or hematological parameters (p's > 0.05). Attendance and adherence rates to aerobic training were 82% and 66%, respectively. Intention-to-treat analysis indicated that VO<subscript>2peak</subscript> increased by 2.6 ± 3.5 ml/kg/min (+ 13.3%) in the AC + AET group and decreased by 1.5 ± 2.2 ml/kg/min (−8.6%) in the AC group (between group difference, p = 0.001). FACT-B increased 11.1 points in the AC + AET group compared to a 1.5 point decrease in the AC group (between group difference, p = 0.685). Conclusion. Moderate-to-high intensity aerobic training when conducted with one-on-one supervision is a safe adjunct therapy associated with improvements in cardiopulmonary function and select PROs during neoadjuvant chemotherapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- BREAST tumor treatment
AEROBIC exercises
CARDIOPULMONARY system
CHI-squared test
COMBINED modality therapy
DOXORUBICIN
ELECTROCARDIOGRAPHY
EXERCISE tests
FISHER exact test
EVALUATION of medical care
PATIENT safety
QUALITY of life
RESEARCH funding
STATISTICAL sampling
SELF-evaluation
T-test (Statistics)
RANDOMIZED controlled trials
CYCLOPHOSPHAMIDE
DATA analysis software
ADVERSE health care events
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 0284186X
- Volume :
- 53
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Acta Oncologica
- Publication Type :
- Academic Journal
- Accession number :
- 93256173
- Full Text :
- https://doi.org/10.3109/0284186X.2013.781673