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Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis.
- Source :
- Journal of Clinical Periodontology; Jan2014, Vol. 41 Issue 1, p70-79, 10p, 1 Diagram, 3 Charts
- Publication Year :
- 2014
-
Abstract
- Aim Systematic review and meta-analyses to study the robustness of observations that treatment of periodontitis improves the atherosclerotic profile. Material and Methods Literature was searched in Medline-PubMed, Cochrane CENTRAL and EMBASE, based on controlled periodontal intervention trials, including also a non-intervention group. Data were extracted and meta-analyses were performed. Results From 3928 screened studies, 25 trials met the eligibility criteria. These trials enrolled 1748 periodontitis patients. Seven trials enrolled periodontitis patients that were otherwise healthy, 18 trials recruited periodontal patients with various co-morbidities, such as CVD or diabetes. None of the trials used hard clinical endpoints of CVD. However, improvement of endothelial function has been consistently reported. Meta-analyses demonstrated significant weighted mean difference (WMD) for hsCRP (−0.50 mg/l, 95% CI:−0.78; −0.22), IL-6 (−0.48 ng/l, 95% CI: −0.90; −0.06), TNF-α (−0.75 pg/ml, 95% CI: −1.34; −0.17), fibrinogen (−0.47 g/l, 95% CI: −0.76; −0.17), total cholesterol (−0.11 mmol/l, 95% CI: −0.21; −0.01) and HDL-C (0.04 mmol/l, 95% CI: 0.03; 0.06) favouring periodontal intervention. Importantly, periodontitis patients with co-morbidity benefitted most from periodontal therapy; significant WMD were observed for levels of hsCRP (−0.71 mg/l, 95% CI: −1.05; −0.36), IL-6 (−0.87 ng/l, 95% CI: −0.97; −0.78), triglycerides (−0.24 mmol/l, 95% CI: −0.26; −0.22), total cholesterol (−0.15 mmol/l, 95% CI: −0.29; −0.01), HDL-C (0.05 mmol/l, 95% CI: 0.03; 0.06) and HbA<subscript>1c</subscript> (−0.43%, 95% CI: −0.60; −0.25). Conclusions This systematic review and meta-analyses demonstrate that periodontal treatment improves endothelial function and reduces biomarkers of atherosclerotic disease, especially in those already suffering from CVD and/or diabetes. [ABSTRACT FROM AUTHOR]
- Subjects :
- PERIODONTITIS treatment
ACADEMIC medical centers
ARTERIOSCLEROSIS
BIOMARKERS
CLINICAL trials
CONFIDENCE intervals
MEDICAL databases
INFORMATION storage & retrieval systems
MEDICAL information storage & retrieval systems
MEDLINE
META-analysis
ONLINE information services
SYSTEMATIC reviews
RANDOMIZED controlled trials
Subjects
Details
- Language :
- English
- ISSN :
- 03036979
- Volume :
- 41
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 92886333
- Full Text :
- https://doi.org/10.1111/jcpe.12171