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Non-human primate models of multiple sclerosis.

Non-human primate models of multiple sclerosis.

Authors :
Brok, Herbert P.M.
Bauer, Jan
Jonker, Margreet
Blezer, Erwin
Amor, Erwin
Bontrop, Ronald E.
Laman, Jon D.
't Hart, Bert A.
Source :
Immunological Reviews; Oct2001, Vol. 183 Issue 1, p173, 13p
Publication Year :
2001

Abstract

The phylogenetic proximity between non-human primate species and humans is reflected by a high degree of immunological similarity. Non-human primates therefore provide important experimental models for disorders in the human population that are caused by the immune system, such as autoimmune diseases. In this paper we describe non-human primate models of multiple sclerosis, a chronic inflammatory and demyelinating disease of the human central nervous system. While reviewing data from the literature and our own research we will discuss the unique role of such models in the research of basic disease mechanisms and the development of new therapies. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
PRIMATES
MULTIPLE sclerosis

Details

Language :
English
ISSN :
01052896
Volume :
183
Issue :
1
Database :
Complementary Index
Journal :
Immunological Reviews
Publication Type :
Academic Journal
Accession number :
9165878
Full Text :
https://doi.org/10.1034/j.1600-065x.2001.1830114.x