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Comparative properties of N-acetyl derivatives of oxime N-methylcarbamates and aryl N-methylcarbamates as insecticides and acetylcholinesterase inhibitors.
- Source :
- Pesticide Science; 1971, Vol. 2 Issue 1, p10-15, 6p
- Publication Year :
- 1971
-
Abstract
- N-acylation of aryl N-methylcarbamates is known to reduce their mammalian toxicity considerably without adversely affecting their insecticidal activity. It has now been found that N-acylation of several insecticidal oxime carbamates results in loss of toxicity both to insects and mammals. Kinetic data for base-catalysed solvolysis and inhibition of acetylcholinesterase, together with published work on metabolism, are combined to provide a rationale for this unexpected observation and to account for the selective toxicity of aryl N-acetyl- N-methylcarbamates. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0031613X
- Volume :
- 2
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Pesticide Science
- Publication Type :
- Academic Journal
- Accession number :
- 91108256
- Full Text :
- https://doi.org/10.1002/ps.2780020104