THE EFFECT OF INDORAMIN ON PERIPHERAL BLOOD FLOW.

The effect of indoramin, a new hypotensive agent, on peripheral blood flows of six normal subjects was determined and compared to placebo in a double-blind, randomized study., Indoramin (0.25 mg/kg), administered intravenously, resulted in an increased forearm muscle volume as measured by strain gauge plethysmography and an increase in the skin temperature of the hand but not to the skin of the chest., It is concluded that these effects are the result of α-adrenoceptor blockade. [ABSTRACT FROM AUTHOR]