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Effect of Radiation Techniques in Treatment of Oropharynx Cancer.
- Source :
- Laryngoscope; 2008, Vol. 118 Issue 4, p635-639, 5p
- Publication Year :
- 2008
-
Abstract
- Objectives: To compare the toxicity and outcomes of three radiotherapy techniques-three-dimensional conformal (3D-RT), accelerated fractionation with concomitant boost (AFxCB), and intensity modulated radiotherapy (IMRT)-in the combined modality treatment of stage III-IV squamous cell carcinoma (SCC) of the oropharynx. Study Design: Retrospective review. Methods: Between 1998 and 2007, a total of 87 patients were treated; 23 were treated with 3D-RT, 32 with AFxCB, and 32 with IMRT. Systemic therapy consisted of platinum-based chemotherapy in 81 and anti-epidermal growth factor receptor (anti-EGFR)-targeted therapy in 6 cases. Median radiotherapy doses were 70Gy with 3D-RT, 72Gy with AFxCB, and 69.3Gy with IMRT. Locoregional control, survival outcomes, and feeding tube (PEG) dependence were compared using log-rank method. The incidence of acute mucositis and skin reaction, and grade ≥2 xerostomia at 6, 12, and 18 months after radiotherapy was compared using Fisher's exact test. Results: Median follow-up was 24 months (range 3 to 103 months) for living patients. Two-year overall survival (OS), disease-free survival (DFS), and locoregional control (LRC) were 77.3%, 69.5%, and 86.4%, respectively. There was a trend toward improvement in LRC in patients treated with IMRT. Acute grade ≥3 skin and mucosal toxicity were significantly lower with IMRT compared to AFxCB ( P < .001). Grade ≥2 xerostomia was significantly reduced with IMRT compared to AFxCB and 3D-RT ( P < .001). There was no difference in the actuarial rate of PEG dependence ( P = .96). Conclusions: Compared to AFxCB and 3D-RT, IMRT confers an improvement in toxicity and appears to have similar efficacy in patients with SCC of the oropharynx. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0023852X
- Volume :
- 118
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Laryngoscope
- Publication Type :
- Academic Journal
- Accession number :
- 90732338
- Full Text :
- https://doi.org/10.1097/MLG.0b013e31815fdf0e