Prognostic Factors in Major Salivary Gland Cancer.

Objective To identify features of major salivary gland cancers that are prognostic for disease-free survival. Study Design A retrospective study of 78 patients with major salivary gland cancer (64 parotid and 14 submandibular gland) who underwent surgery for definitive treatment from 1976 to 1996. A select group of patients also received adjuvant radiation (56%) and/or chemotherapy (13%). Method Clinical and pathological risk factors were obtained from patients' charts and pathology reports. Age, gender, tumor site, T-stage, facial paralysis, histologic neck involvement, perineural invasion, and cancer grade were analyzed with respect to disease-free survival. The role of adjuvant treatment in terms of clinical outcome was also investigated. Results In our series, the 5-year disease-free survival was 65%. Examining clinical and histologic features one at a time, we found poorer prognosis was associated with submandibular tumors compared with parotid ( P = .02), higher T-stage ( P = .001), positive cervical nodes ( P <.001), perineural invasion ( P = .002), and high-grade or adenoid cystic tumors ( P = .002). A multivariable analysis indicated that positive lymph nodes ( P = .07) and perineural invasion ( P = .03) were important histologic predictors of shorter disease-free survival. Receipt of both adjuvant radiation and cisplatin-based chemotherapy ( P = .05) was an independent predictor of longer disease-free survival. Conclusion Our study indicated that the presence of positive lymph nodes and perineural invasion is important independent predictors of disease-free survival. Our limited data also suggest that adjuvant chemotherapy and radiation therapy may improve disease-free survival. [ABSTRACT FROM AUTHOR]