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Geographically Structured Populations of Cryptococcus neoformans Variety grubii in Asia Correlate with HIV Status and Show a Clonal Population Structure.

Authors :
Khayhan, Kantarawee
Hagen, Ferry
Pan, Weihua
Simwami, Sitali
Fisher, Matthew C.
Wahyuningsih, Retno
Chakrabarti, Arunaloke
Chowdhary, Anuradha
Ikeda, Reiko
Taj-Aldeen, Saad J.
Khan, Ziauddin
Ip, Margaret
Imran, Darma
Sjam, Ridhawati
Sriburee, Pojana
Liao, Wanqing
Chaicumpar, Kunyaluk
Vuddhakul, Varaporn
Meyer, Wieland
Trilles, Luciana
Source :
PLoS ONE; Sep2013, Vol. 8 Issue 9, p1-14, 14p
Publication Year :
2013

Abstract

Cryptococcosis is an important fungal disease in Asia with an estimated 140,000 new infections annually the majority of which occurs in patients suffering from HIV/AIDS. Cryptococcus neoformans variety grubii (serotype A) is the major causative agent of this disease. In the present study, multilocus sequence typing (MLST) using the ISHAM MLST consensus scheme for the C. neoformans/C. gattii species complex was used to analyse nucleotide polymorphisms among 476 isolates of this pathogen obtained from 8 Asian countries. Population genetic analysis showed that the Asian C. neoformans var. grubii population shows limited genetic diversity and demonstrates a largely clonal mode of reproduction when compared with the global MLST dataset. HIV-status, sequence types and geography were found to be confounded. However, a correlation between sequence types and isolates from HIV-negative patients was observed among the Asian isolates. Observations of high gene flow between the Middle Eastern and the Southeastern Asian populations suggest that immigrant workers in the Middle East were originally infected in Southeastern Asia. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19326203
Volume :
8
Issue :
9
Database :
Complementary Index
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
90530479
Full Text :
https://doi.org/10.1371/journal.pone.0072222