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Efficacy of a new mouth rinse formulation based on 0.07% cetylpyridinium chloride in the control of plaque and gingivitis: a 6-month randomized clinical trial.
- Source :
- Journal of Clinical Periodontology; Nov2013, Vol. 40 Issue 11, p1007-1015, 9p, 1 Diagram, 8 Charts
- Publication Year :
- 2013
-
Abstract
- Aim To assess the efficacy of a 0.07% cetylpyridinium chloride ( CPC) mouth rinse in the control of plaque and gingival inflammation during a 6-month period. Material and Methods Adult subjects with moderate gingivitis were selected [≥40% bleeding on marginal probing ( BOMP)]. After retrieving microbiological samples and evaluating the clinical parameters (plaque, BOMP and stain indexes), a professional prophylaxis was performed and subjects were randomly assigned to the test ( CPC mouth rinse) or to the placebo group. Subjects were re-assessed after 3 and 6 months. Results A total of 67 patients (35 test, 32 placebo) were included in the analysis. At 6 months, intra-group significant plaque reductions were observed in the test group (0.691, p < 0.001), but not in the placebo (0.181, p = 0.653). At 6 months, the mean BOMP values were lower in the test group ( p = 0.052). Changes between baseline and 6 months were significantly higher in the test group both for plaque ( p = 0.002) and BOMP ( p = 0.037) when compared with the placebo. A microbiological impact was observed in the test group, especially for Prevotella intermedia. Conclusion The evaluated 0.07% CPC-based mouth rinse, used three times per day adjunctively to mechanical tooth cleaning, prevents plaque accumulation and gingival inflammation, as compared to the placebo, for at least 6 months. [ABSTRACT FROM AUTHOR]
- Subjects :
- DENTAL plaque
GINGIVITIS
CHLORIDES
ACADEMIC medical centers
ANALYSIS of variance
CHI-squared test
FISHER exact test
HEALTH outcome assessment
PLACEBOS
RESEARCH funding
STATISTICS
T-test (Statistics)
DATA analysis
RANDOMIZED controlled trials
TREATMENT effectiveness
DATA analysis software
DESCRIPTIVE statistics
PREVENTION
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 03036979
- Volume :
- 40
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 90526234
- Full Text :
- https://doi.org/10.1111/jcpe.12158