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Distinguishing Score 0 From Score 1+ in HER2 Immunohistochemistry-Negative Breast Cancer.
- Source :
- American Journal of Clinical Pathology; Oct2013, Vol. 140 Issue 4, p561-566, 6p, 6 Charts
- Publication Year :
- 2013
-
Abstract
- Objectives: To investigate the clinical and pathobiological significance of distinguishing score 0 and score 1+ within the group of immunohistochemistry (IHC)-negative invasive breast cancers. Methods: We studied HER2 status using both IHC and fluorescence in situ hybridization (FISH) in 150 consecutive breast tumors submitted to our laboratory after a negative IHC result in local testing centers. Results: We were able to discern a group of score 0 tumors that had a lower HER2 copy number than the group consisting of score 1+ tumors. In contrast with the group of score 1+ tumors, HER2 FISH was consistently negative for both copy number-based and ratio-based tumors without equivocal results. Conclusions: In a setting with stringent quality assurance, score 0 and score 1+ tumors emerge as distinct and clinically important subgroups within the HER2 IHC-negative population. [ABSTRACT FROM AUTHOR]
- Subjects :
- HER2 gene
PROTO-oncogenes
IMMUNOHISTOCHEMISTRY
HISTOCHEMISTRY
BREAST cancer
Subjects
Details
- Language :
- English
- ISSN :
- 00029173
- Volume :
- 140
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 90282930
- Full Text :
- https://doi.org/10.1309/AJCP4A7KTAYHZSOE