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PPARγ and PPARGC1B polymorphisms modify the association between phthalate metabolites and breast cancer risk.
- Source :
- Biomarkers; Sep2013, Vol. 18 Issue 6, p493-501, 9p, 5 Charts
- Publication Year :
- 2013
-
Abstract
- Context: Breast cancer (BC) risk has been differentially associated with urinary levels of some phthalate metabolites. Objective: To investigate whether PPARγ and PPARGC1B polymorphisms modulate these associations. Materials and methods: 208 BC cases were age-matched with 220 population controls. Phthalate metabolites were determined by HPLC-MS. PPARγ Pro12Ala (rs1801281) and PPARGCW Ala203Pro (rs7732671) and Val279lle (rs17572019) were genotyped. Results: The association between mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and BC risk was positively modified in PPARγ Pro12Ala C carriers. The association with mono-iso-butyl phthalate (MiBP) in PPARGCW Ala203Pro G carriers was negatively modified. Conclusion: PPARγ and PPARGC1B polymorphisms modulate the association between phthalate exposure and BC risk. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1354750X
- Volume :
- 18
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 90250878
- Full Text :
- https://doi.org/10.3109/1354750X.2013.816776