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Cancer risk in Lynch Syndrome.

Authors :
Barrow, Emma
Hill, James
Evans, D.
Source :
Familial Cancer; Jun2013, Vol. 12 Issue 2, p229-240, 12p
Publication Year :
2013

Abstract

Lynch Syndrome, or hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by inactivating mutations in DNA mismatch repair genes. It accounts for 2-4 % of all incident colorectal cancers. Mutation carriers are at risk of early onset colorectal cancer, endometrial cancer, and a spectrum of other tumours. Accurate estimation of cancer risk for mutation carriers is essential for counselling, and establishing appropriate screening guidelines. This study reviews the current data on cancer risk, and emerging risk reduction strategies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13899600
Volume :
12
Issue :
2
Database :
Complementary Index
Journal :
Familial Cancer
Publication Type :
Academic Journal
Accession number :
89220473
Full Text :
https://doi.org/10.1007/s10689-013-9615-1