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Cancer risk in Lynch Syndrome.
- Source :
- Familial Cancer; Jun2013, Vol. 12 Issue 2, p229-240, 12p
- Publication Year :
- 2013
-
Abstract
- Lynch Syndrome, or hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by inactivating mutations in DNA mismatch repair genes. It accounts for 2-4 % of all incident colorectal cancers. Mutation carriers are at risk of early onset colorectal cancer, endometrial cancer, and a spectrum of other tumours. Accurate estimation of cancer risk for mutation carriers is essential for counselling, and establishing appropriate screening guidelines. This study reviews the current data on cancer risk, and emerging risk reduction strategies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13899600
- Volume :
- 12
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Familial Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 89220473
- Full Text :
- https://doi.org/10.1007/s10689-013-9615-1