Back to Search
Start Over
Calcium-dependent Ret activation by GDNF and neurturin.
- Source :
- Oncogene; 1/22/98, Vol. 16 Issue 3, p293, 7p
- Publication Year :
- 1998
-
Abstract
- Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) define a new family of neurotrophic factors that play crucial roles in survival and differentiation of various neurons. Recent studies demonstrated that GDNF and NTN use a multicomponent receptor system in which glycosyl-phosphatidylinositol (GPI)-linked cell surface proteins and Ret receptor tyrosine kinase function as the ligand-binding and signalling components, respectively. In the present study, we investigated the role of Ca<superscript>2+</superscript> ions for biochemical and biological activities of Ret because Ret has a unique structure of the extracellular domain with the cadherin-like motif. The results demonstrated that Ca<superscript>2+</superscript> ions might be required for the complex formation of Ret and GDNF or NTN that induces Ret oligomerization and autophosphorylation. Full morphological differentiation of neuroblastoma cells by these neurotrophic factors was also Ca<superscript>2+</superscript>-dependent. These findings thus suggested that, in addition to GPI-linked cell surface proteins, Ca<superscript>2+</superscript> ions are components of the signal transducing complex formed by Ret and GDNF protein family. [ABSTRACT FROM AUTHOR]
- Subjects :
- NEUROGLIA
PROTEIN-tyrosine kinases
CELL membranes
Subjects
Details
- Language :
- English
- ISSN :
- 09509232
- Volume :
- 16
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Oncogene
- Publication Type :
- Academic Journal
- Accession number :
- 8918154
- Full Text :
- https://doi.org/10.1038/sj.onc.1201548