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Bone Marrow Findings in HIV-Positive Patients With Kaposi Sarcoma Herpesvirus-Associated Multicentric Castleman Disease.
- Source :
- American Journal of Clinical Pathology; May2013, Vol. 139 Issue 5, p651-661, 11p, 6 Color Photographs, 1 Black and White Photograph, 2 Charts
- Publication Year :
- 2013
-
Abstract
- Kaposi sarcoma herpesvirus (KSHV), also known as human herpesvirus-8, is associated with 1 form of multicentric Castleman disease (MCD) and is the etiologic agent for most MCD in human immunodeficiency virus (HIV)-infected patients. Diagnosis is usually determined by lymph node biopsy. Bone marrow findings in KSHV-MCD are not well characterized. We conducted histomorphologic and immunohistochemical evaluation of bone marrow biopsy specimens in HIV-infected patients with KSHV-MCD, including evaluation for KSHV latency-associated nuclear antigen. Findings were correlated with clinical features and KSHV viral load. Reactive plasmacytosis was the predominant feature. Lymphoid aggregates were less common and not diagnostic of KSHV-MCD. Forty-eight percent of cases contained scattered KSHV-infected mononuclear cells. Although patients were generally cytopenic, bone marrow biopsy specimens were normocellular to hypercellular except in patients receiving hematotoxic therapy. Bone marrow biopsy specimens in KSHV-MCD patients recapitulate findings of interleukin-6 excess. In patients with HIV, unexplained cytopenias, and bone marrow plasmacytosis, evaluation for KSHV-MCD is warranted. [ABSTRACT FROM AUTHOR]
- Subjects :
- KAPOSI'S sarcoma
HERPESVIRUS diseases
CASTLEMAN'S disease
LYMPH nodes
INTERLEUKIN-6
Subjects
Details
- Language :
- English
- ISSN :
- 00029173
- Volume :
- 139
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 89132294
- Full Text :
- https://doi.org/10.1309/AJCPKGF7U8AWQBVG