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Myocardial sympathetic innervation, function, and oxidative metabolism in non-infarcted myocardium in patients with prior myocardial infarction.
- Source :
- Annals of Nuclear Medicine; Jul2013, Vol. 27 Issue 6, p523-531, 9p
- Publication Year :
- 2013
-
Abstract
- Objective: The purpose of this study was to investigate the relationship between sympathetic innervation, contractile function, and the oxidative metabolism of the non-infarcted myocardium in patients with prior myocardial infarction. Methods: In 19 patients (14 men, 5 women, 65 ± 9 years) after prior myocardial infarction, sympathetic innervation was assessed by C-hydroxyephedrine (HED) positron emission tomography (PET). Oxidative metabolism was quantified using C-acetate PET. Left ventricular systolic function was measured by echocardiography with speckle tracking technique. Results: The C-HED retention was positively correlated with left ventricular ejection fraction (LVEF) ( r = 0.566, P < 0.05), and negatively with peak longitudinal strain in systole in the non-infarcted myocardium ( r = −0.561, P < 0.05). Kmono, as an index of oxidative metabolism, was significantly correlated with rate pressure product ( r = 0.649, P < 0.01), but not with C-HED retention ( r = 0.188, P = 0.442). Furthermore, there was no significant correlation between Kmono and LVEF ( r = 0.106, P = 0.666) or peak longitudinal strain in systole ( r = −0.256, P = 0.291) in the non-infarcted myocardium. When the patients were divided into two groups based on the median value of left ventricular end-systolic volume index (LVESVI) (41 mL), there were no significant differences in age, sex, and rate pressure product between the groups. However, the large LVESVI group (>41 mL) was associated with reduced C-HED retention and peak longitudinal strain in systole, whereas Kmono was similar between the groups. Conclusions: This study indicates that remodeled LV after myocardial infarction is associated with impaired sympathetic innervation and function even in the non-infarcted myocardial tissue. Furthermore, oxidative metabolism in the non-infarcted myocardium seems to be operated by normal regulatory mechanisms rather than pre-synaptic sympathetic neuronal function. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09147187
- Volume :
- 27
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Annals of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 89077583
- Full Text :
- https://doi.org/10.1007/s12149-013-0716-6