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High versus low radioiodine activity in patients with differentiated thyroid cancer: A meta-analysis.
- Source :
- Acta Oncologica; Aug2013, Vol. 52 Issue 6, p1055-1061, 7p, 1 Diagram, 3 Charts, 1 Graph
- Publication Year :
- 2013
-
Abstract
- Background. The purpose of the meta-analysis was to estimate the effectiveness and toxicity of low activity radioiodine ablation versus high activity in patients with differentiated thyroid cancer (DTC). Design. A systematic review and meta-analysis was performed by including all randomized trials of low activity versus high activity radioiodine ablation after thyroidectomy. Standard meta-analytic procedures were used to analyze the study outcomes. Results. Ten trials were considered eligible and were further analyzed. The pooled risk ratio (RR) of having a successful ablation for an activity of 1100 MBq versus 3700 MBq (seven trials, 1772 patients) was 0.94 (95% CI 0.85-1.04, p-value = 0.21). The RR for successful ablation when only thyroid hormone withdrawal was used (five trials, 1116 patients) was 0.87 (95% CI 0.72-1.06, p-value = 0.17) and it was comparable to RR when only recombinant-human TSH (rec-hTSH) (two trials, 812 patients) was used (1.00, 95% CI 0.93-1.07, p-value = 0.92). Salivary dysfunction, nausea, and neck pain were significantly more frequent among patients with higher dose for ablation. Conclusion. Our meta-analysis provides some evidence from randomized trials that a lower activity of radioiodine ablation is as effective as higher dose after surgery in patients with DTC with lower toxicity. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of iodine isotopes
RADIOISOTOPE therapy
CANCER relapse
CHI-squared test
CONFIDENCE intervals
EPIDEMIOLOGY
MEDICAL databases
INFORMATION storage & retrieval systems
IODINE isotopes
MEDLINE
META-analysis
RADIOISOTOPES
THYROID gland tumors
SYSTEMATIC reviews
DATA analysis
ABLATION techniques
DATA analysis software
DESCRIPTIVE statistics
PROGNOSIS
TUMOR treatment
Subjects
Details
- Language :
- English
- ISSN :
- 0284186X
- Volume :
- 52
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Acta Oncologica
- Publication Type :
- Academic Journal
- Accession number :
- 88958283
- Full Text :
- https://doi.org/10.3109/0284186X.2012.742959