Mechanism and function of Vav1 localisation in TCR signalling.

The article discusses antigen-specific activation of T cells. According to the article, It is triggered by the binding of the cell surface T cell antigen receptor (TCR) to antigenic peptide bound to MHC molecules (pMHC) on the surface of anantigen-presenting cell (APC). The Vav1 guanine nucleotide exchange factor plays an importatl role in T cell antigen receptor (TCR) signalling, leading to the activation of multiple pathways. The authors propose that Vav1 is recruited to the IS by binding to SLP76 and that this interaction is critical for the transduction of signals leading to calcium flux.