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Mobilizing potential of ifosfamide/vinorelbine-based chemotherapy in pretreated malignant lymphoma.
- Source :
- Bone Marrow Transplantation; 11/15/2001, Vol. 28 Issue 10, p923, 5p, 2 Charts
- Publication Year :
- 2001
-
Abstract
- The mobilizing potential and therapeutic activity of ifosfamide/vinorelbine-containing regimens with G-CSF support were explored in patients with pretreated malignant lymphomas. Ten patients with non-Hodgkin’s lymphoma (NHL) received ifosfamide and vinorelbine, and 17 with Hodgkin’s disease (HD) received ifosfamide, vinorelbine and gemcitabine (IGEV regimen), as induction chemotherapy before high-dose chemotherapy (HDT) with peripheral blood stem cell (PBSC) support. Most of the patients had been heavily pretreated with various chemotherapy regimens ± radiotherapy. The target yield was 3 × 10<superscript>6</superscript> CD34<superscript>+</superscript> cells/kg of body weight in order to support the subsequent myeloablative chemotherapy. The optimal PBSC harvest occurred on days 11 and 12, with no difference in CD34<superscript>+</superscript> cell mobilization kinetics between the ifos- famide/vinorelbine and IGEV regimens. The median number of CD34<superscript>+</superscript> cells/kg body weight collected was 10.9 × 10<superscript>6</superscript> (range 1.76–61.1 × 10<superscript>6</superscript>). The median total CD34<superscript>+</superscript> cell/μl, CFU-GM and white blood cells (WBC) for all individual collections was 81.5/μl, 10 × 10<superscript>4</superscript>/kg, and 17 900/μl, respectively. The target yield of CD34<superscript>+</superscript> cells was reached in 24 of 27 patients. Hematological side-effects were acceptable and no treatment-related hospitalizations or toxic deaths occurred. Fifteen patients have so far received high-dose therapy and PBSC reinfusion with rapid engraftment. These results confirm that ifosfamide and vinorelbine-based chemotherapy regimen with G-CSF support can be successfully and safely used to mobilize PBSCs. Bone Marrow Transplantation (2001) 28, 923–927. [ABSTRACT FROM AUTHOR]
- Subjects :
- HODGKIN'S disease
COMBINATION drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 02683369
- Volume :
- 28
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Bone Marrow Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 8889330
- Full Text :
- https://doi.org/10.1038/sj.bmt.1703265