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Three new guaiane sesquiterpene lactones from rhizomes of Curcuma wenyujin.
- Source :
- Journal of Asian Natural Products Research; Jul2013, Vol. 15 Issue 7, p723-730, 8p, 3 Diagrams, 3 Charts, 2 Graphs
- Publication Year :
- 2013
-
Abstract
- Three new guaiane sesquiterpene lactones (4S)-4-hydroxy-gweicurculactone (1), zedoalactone G (2), and (1R, 4R, 5S, 10S)-zedoalactone B (3), and three known guaiane sesquiterpene lactones, including zedoarolide B (4), zedoalactone B (5), and a new natural product (+)-zedoalactone A (6), were isolated from the rhizomes of Curcuma wenyujin Y.H. Chen et C. Ling. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and HR-ESI-MS. The absolute configuration of 2 was determined via the calculated electronic circular dichroism (ECD), whereas the absolute configurations of 1 and 3 were determined via the ECD data of the [Rh<subscript>2</subscript>(OCOCF<subscript>3</subscript>)<subscript>4</subscript>] complex and [Mo<subscript>2</subscript>(OAc)<subscript>4</subscript>] complex, respectively. The inhibitory effects of compounds 1–6 on nitric oxide production in lipopolysaccharide-activated macrophages were evaluated. All of them exhibited weak anti-inflammatory activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- ORGANIC compound analysis
ANIMAL experimentation
BIOLOGICAL assay
CELL culture
HIGH performance liquid chromatography
MASS spectrometry
MICE
MOLECULAR structure
NITRIC oxide
NUCLEAR magnetic resonance spectroscopy
ORGANIC compounds
PHARMACEUTICAL chemistry
RESEARCH funding
PLANT stems
TERPENES
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 15
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 88893131
- Full Text :
- https://doi.org/10.1080/10286020.2013.796936