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TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice.
- Source :
- Nature Immunology; Jul2001, Vol. 2 Issue 7, p632, 6p
- Publication Year :
- 2001
-
Abstract
- Interactions of the tumor necrosis factor superfamily members B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) with their receptors?transmembrane activator and CAML interactor (TACI) and B cell maturation molecule (BCMA)?on B cells play an important role in the humoral immune response. Whereas BCMA is restricted to B cells, TACI is also expressed on activated T cells; we show here that TACI-Fc blocks the activation of T cells in vitro and inhibits antigen-specific T cell activation and priming in vivo. In a mouse model for rheumatoid arthritis (RA), an autoimmune disease that involves both B and T cell components, TACI-Fc treatment substantially inhibited inflammation, bone and cartilage destruction and disease development. Thus, BLyS and/or APRIL are important not only for B cell function but for T cell?mediated immune responses. Inhibition of these ligands might have therapeutic benefits for autoimmune diseases, such as RA, that involve both B and T cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- TUMOR necrosis factors
T cells
ARTHRITIS
Subjects
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 2
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 8837626
- Full Text :
- https://doi.org/10.1038/89782