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SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P.

SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P.

Authors :
Xu, Yue
Hortsman, Heinz
Seet, Lifong
Wong, Siew Heng
Hong, Wanjin
Source :
Nature Cell Biology; Jul2001, Vol. 3 Issue 7, p658, 9p
Publication Year :
2001

Abstract

The sorting nexin (SNX) protein family is implicated in regulating membrane traffic, but the mechanism is still unknown. We show that SNX3 is associated with the early endosome through a novel motif (PX domain) capable of interaction with phosphatidylinositol-3-phosphate (Ptdlns(3)P). Overexpression of SNX3 alters endosomal morphology and delays transport to the lysosome. Transport from the early to the recycling endosome is affected upon microinjection of SNX3 antibodies. Our results highlight a novel mechanism by which SNX proteins regulate traffic and uncover a novel class of effectors for Ptdlns(3)P. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
PROTEINS
CELL membranes

Details

Language :
English
ISSN :
14657392
Volume :
3
Issue :
7
Database :
Complementary Index
Journal :
Nature Cell Biology
Publication Type :
Academic Journal
Accession number :
8837366
Full Text :
https://doi.org/10.1038/35083051