Effect of Single Stage Caffeine Supplementation on CK and IL-6 Responses in Non-Active Male after an Exhaustive Aerobic Exercise.

Backgrounds and Objectives: caffeine is a member of methyl xanthine family which can further facilitate exercise because of its antioxidant activity it could be effective for prevention of cellular damage. The purpose of this study was to evaluate single stage caffeine supplementation on CK and IL-6 responses in non-active male after an exhaustive aerobic exercise. Materials and Methods: 20 non-active male students randomly divided as supplementation and control groups. Exercise test was an exhaustive treadmill test (Bruce test). One hour before the exercise, supplementation group received caffeine (6 Mg/BW) and control group receive placebo. Blood samples were collected before and immediately after exercise test from anticubital vein. Serum; Lactate, CK were measured by Spectrophotometric method and serum IL-6 concentrations were determined using ELISA. Data analysis was used performed using the mixed ANOVA and paired t test. Results: Data analysis showed that a significant increments in blood lactate, creatine kinase and interleukin-6 levels in both control and supplement group (P<0.05). Mixed ANOVA analysis showed that caffeine supplementation had a significant effect on serum interleukin 6 in non-active men after exhaustive aerobic exercise (P<0.05), but its effect on creatine kinase and lactate markers was not significant (P>0.05). Conclusion: According to the results of present study, Caffeine supplementation has positive effect on muscle damage of non-active male after exhaustive aerobic exercise. [ABSTRACT FROM AUTHOR]