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Therapy model for advanced intracerebral B16 mouse melanoma using radiation therapy combined with immunotherapy.
- Source :
- Cancer Immunology, Immunotherapy; Jul2013, Vol. 62 Issue 7, p1187-1197, 11p
- Publication Year :
- 2013
-
Abstract
- The article looks at a reproducible therapy model for advanced intracerebral B16 melanoma. It is noted that implanted tumors suppressed by a single radiosurgical dose of 100 kVp X-rays were further suppressed by a single ip injection of a Treg-depleting mAb given two days prior to the initiation of four weekly then eight bi-monthly sc injections of GMCSF-transfeced, mitotically disabled B16 cells. This treatment course reduced tumors in mice.
Details
- Language :
- English
- ISSN :
- 03407004
- Volume :
- 62
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Cancer Immunology, Immunotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 88286406
- Full Text :
- https://doi.org/10.1007/s00262-013-1423-9