Therapy model for advanced intracerebral B16 mouse melanoma using radiation therapy combined with immunotherapy.

The article looks at a reproducible therapy model for advanced intracerebral B16 melanoma. It is noted that implanted tumors suppressed by a single radiosurgical dose of 100 kVp X-rays were further suppressed by a single ip injection of a Treg-depleting mAb given two days prior to the initiation of four weekly then eight bi-monthly sc injections of GMCSF-transfeced, mitotically disabled B16 cells. This treatment course reduced tumors in mice.