NOVEL ARYL SUBSTITUTED BICYCLIC FURO NUCLEOSIDES AS EXTREMELY POTENT AND SELECTIVE ANTI-VZV AGENTS.

Authors :: McGuigan, Christopher
Barucki, Hubert
Carangio, Antonella
Blewett, Sally
Srinivasan, Sheila
Andrei, Graciela
Snoeck, Robert
De Clercq, Erik
Balzarini, Jan
Source :: Nucleosides, Nucleotides & Nucleic Acids; Apr2001, Vol. 20 Issue 4-7, p287-296, 10p, 1 Chart
Publication Year :: 2001
Abstract: Reports on the discovery that a synthetic by-product in the preparation of the parent 5-alkynyl nucleosides displayed prominent potency and exclusive selectivity for Varicella-Zoster Virus (VZV). Possible development of topical applications; Details of experiments; Conclusion that the p-alkylaryl series of furo pyrimidine nucleosides could be a potential treatment for herpes zoster.

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