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ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer

Authors :
Kalyuga, Maria
Gallego-Ortega, David
Lee, Heather J.
Roden, Daniel L.
Cowley, Mark J.
Caldon, C. Elizabeth
Stone, Andrew
Allerdice, Stephanie L.
Valdes-Mora, Fatima
Launchbury, Rosalind
Statham, Aaron L.
Armstrong, Nicola
Alles, M. Chehani
Young, Adelaide
Egger, Andrea
Au, Wendy
Piggin, Catherine L.
Evans, Cara J.
Ledger, Anita
Brummer, Tilman
Source :
PLoS Biology; Dec2012, Vol. 10 Issue 12, p1-17, 17p, 6 Diagrams, 2 Graphs
Publication Year :
2012

Abstract

The transcription factor ELF5 is responsible for gene expression patterning underlying molecular subtypes of breast cancer and may mediate acquired resistance to anti-estrogen therapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15449173
Volume :
10
Issue :
12
Database :
Complementary Index
Journal :
PLoS Biology
Publication Type :
Academic Journal
Accession number :
88193555
Full Text :
https://doi.org/10.1371/journal.pbio.1001461