The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

Authors :: Xiong, Xin
Hao, Yan
Sun, Kan
Li, Jiaxing
Li, Xia
Mishra, Bibhudatta
Soppina, Pushpanjali
Wu, Chunlai
Hume, Richard I.
Collins, Catherine A.
Source :: PLoS Biology; Dec2012, Vol. 10 Issue 12, p1-18, 18p, 8 Color Photographs, 1 Black and White Photograph
Publication Year :: 2012
Abstract: Highwire, a conserved axonal E3 ubiquitin ligase, regulates the initiation of axonal degeneration after injury in Drosophila by regulating the levels of the NAD+ biosynthetic enzyme, Nmnat, and the Wnd kinase. [ABSTRACT FROM AUTHOR]

Subjects :: UBIQUITIN ligases
AXONAL transport
LABORATORY mice
NEURODEGENERATION
DROSOPHILA

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