Back to Search
Start Over
Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats.
Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats.
- Source :
- Pharmacognosy Research; Jul-Sep2013, Vol. 5 Issue 3, p150-156, 7p, 1 Color Photograph, 5 Charts
- Publication Year :
- 2013
-
Abstract
- Background: Various hepatoprotective herbal products from plants are available in Mexico, where up to 85% of patients with liver disease use some form of complementary and alternative medicine. However, only few studies have reported on the biological evaluation of these products. Objective: Using a model of carbon tetrachloride (CCl<subscript>4</subscript>)-induced hepatotoxicity in rats, we evaluated the effects of commercial herbal extracts used most commonly in the metropolitan area of Monterrey, Mexico. Materials and Methods: The commercial products were identified through surveys in public areas. The effect of these products given with or without CCl<subscript>4</subscript> in rats was evaluated by measuring the serum concentrations of aspartate amino transferase (AST) and alanine amino transferase (ALT), and histopathological analysis. Legalon® was used as the standard drug. Results: The most commonly used herbal products were Hepatisan® capsules, Boldo capsules, Hepavida® capsules, Boldo infusion, and milk thistle herbal supplement (80% silymarin). None of the products tested was hepatotoxic according to transaminase and histological analyses. AST and ALT activities were significantly lower in the Hepavida+CCl<subscript>4</subscript>-treated group as compared with the CCl<subscript>4</subscript>-only group. AST and ALT activities in the silymarin, Hepatisan, and Boldo tea groups were similar to those in the CCl<subscript>4</subscript> group. The CCl<subscript>4</subscript> group displayed submassive confluent necrosis and mixed inflammatory infiltration. Both the Hepatisan+CCl<subscript>4</subscript> and Boldo tea+CCl<subscript>4</subscript> groups exhibited ballooning degeneration, inflammatory infiltration, and lytic necrosis. The silymarin+CCl<subscript>4</subscript> group exhibited microvesicular steatosis. The Hepavida+CCl<subscript>4</subscript>- and Legalon+CCL<subscript>4</subscript>-treated groups had lower percentages of necrotic cells as compared with the CCl<subscript>4</subscript>-treated group; this treatment was hepatoprotective against necrosis. Conclusion: Only Hepavida had a hepatoprotective effect. [ABSTRACT FROM AUTHOR]
- Subjects :
- LABORATORY mice
HERBAL medicine
PLANT extracts
PHARMACOGNOSY
HEPATOTOXICOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 09764836
- Volume :
- 5
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Pharmacognosy Research
- Publication Type :
- Academic Journal
- Accession number :
- 88054035
- Full Text :
- https://doi.org/10.4103/0974-8490.112417