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Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats.

Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats.

Authors :
Cordero-Pérez, Paula
Torres-González, Liliana
Aguirre-Garza, Marcelino
Camara-Lemarroy, Carlos
La Garza, Francisco Guzmán-de
Alarcón-Galván, Gabriela
Zapata-Chavira, Homero
de JesúsSotelo-Gallegos, Ma.
Torres-Esquivel, Cipactli Nadjedja
Sánchez-Fresno, Ethel
Cantú-Sepúlveda, Daniel
González-Saldivar, Gerardo
Bernal-Ramirez, Judith
Muñoz-Espinosa, Linda E.
Source :
Pharmacognosy Research; Jul-Sep2013, Vol. 5 Issue 3, p150-156, 7p, 1 Color Photograph, 5 Charts
Publication Year :
2013

Abstract

Background: Various hepatoprotective herbal products from plants are available in Mexico, where up to 85% of patients with liver disease use some form of complementary and alternative medicine. However, only few studies have reported on the biological evaluation of these products. Objective: Using a model of carbon tetrachloride (CCl<subscript>4</subscript>)-induced hepatotoxicity in rats, we evaluated the effects of commercial herbal extracts used most commonly in the metropolitan area of Monterrey, Mexico. Materials and Methods: The commercial products were identified through surveys in public areas. The effect of these products given with or without CCl<subscript>4</subscript> in rats was evaluated by measuring the serum concentrations of aspartate amino transferase (AST) and alanine amino transferase (ALT), and histopathological analysis. Legalon® was used as the standard drug. Results: The most commonly used herbal products were Hepatisan® capsules, Boldo capsules, Hepavida® capsules, Boldo infusion, and milk thistle herbal supplement (80% silymarin). None of the products tested was hepatotoxic according to transaminase and histological analyses. AST and ALT activities were significantly lower in the Hepavida+CCl<subscript>4</subscript>-treated group as compared with the CCl<subscript>4</subscript>-only group. AST and ALT activities in the silymarin, Hepatisan, and Boldo tea groups were similar to those in the CCl<subscript>4</subscript> group. The CCl<subscript>4</subscript> group displayed submassive confluent necrosis and mixed inflammatory infiltration. Both the Hepatisan+CCl<subscript>4</subscript> and Boldo tea+CCl<subscript>4</subscript> groups exhibited ballooning degeneration, inflammatory infiltration, and lytic necrosis. The silymarin+CCl<subscript>4</subscript> group exhibited microvesicular steatosis. The Hepavida+CCl<subscript>4</subscript>- and Legalon+CCL<subscript>4</subscript>-treated groups had lower percentages of necrotic cells as compared with the CCl<subscript>4</subscript>-treated group; this treatment was hepatoprotective against necrosis. Conclusion: Only Hepavida had a hepatoprotective effect. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09764836
Volume :
5
Issue :
3
Database :
Complementary Index
Journal :
Pharmacognosy Research
Publication Type :
Academic Journal
Accession number :
88054035
Full Text :
https://doi.org/10.4103/0974-8490.112417